AGS Therapeutics (www.ags-tx.com) is a preclinical-stage biotech company pioneering microalgae extracellular vesicles (MEVs) as a new, universal, delivery system for innovative therapeutics. MEVs have shown to be a safe, targeted and highly versatile delivery system for innovative biologics, such as mRNA, siRNA, DNA, plasmids, and proteins for a broad range of human diseases.
AGS-M (www.ags-m.com), the contract development and manufacturing organization (CDMO) subsidiary, produces the MEV needed to support preclinical and clinical development of MEV-based product pipelines from AGS and from pharmaceutical partners of AGS. AGS’ MEVs are derived from Chlorella, a two-billion-year-old single-cell algae, classified as GRAS, and used for decades as a food supplement.
With a strong IP position and an experienced and dedicated team onboard, AGS works on proprietary technology platforms including microalgae cell engineering, biomolecule design, biopharmaceutical product development in vitro and in vivo, MEVs manufacturing at lab and pre-industrial scale, MEVs bio-analytics and characterization.
We are seeking to hire motivated professionals with experience in life sciences, engineering, and biotechnology to join the team and help us build and lead a novel, green generation of biopharmaceuticals.
■ Be involved in the design, execution, and analysis of research and development activitiesincluding (1) design and development of novel product candidates for the MEV-mediated treatment of diseases, (2) in vitro studies related to the efficacy of MEV-mediated delivery in relevant cell types (by genetic analysis (qPCR, RT-PCR), immunofluorescence, molecular and cell-based assays, amongother), (3) the use of MEVs for the treatment of disorders, (4) outsourced in vivo studies of MEV-mediated delivery and expression of payload in different tissues, (5) the therapeutic effect of MEV-mediated treatment, (6) thetoxicity, tolerability, and immunogenicity of MEV-mediated delivery to specific organs and tissues, (7) in vitro or in vivo studies on the cellular and molecular mechanisms involved in the biological activity of the MEVs, or their payload in different tissues, (8) among other opportunely decided.
■ Independently search and analyse scientific publications to design studies and choose experimental methodology.
■ Provide expertise and insight to guide research and development on AGS’ approach to the treatment of specific diseases.
■ Generate, compile, and analyse experimental data to generate knowledge and decide on next steps.
■ Write research and development reports and ensure their timely delivery.
■ Prepare and present project updates to upper management.
■ Ensure a continuous improvement within research and development activities.
■ Fully comply with traceability and quality assurance procedures in place within AGS.
■ Ensure compliance with all existing safety standards in the area of responsibility, taking into account laws, regulations and directives.
■ Participate in scientificpublications and patent applications.
■ Search and analysis of scientific and technical publications to design processes and choose relevant methodology.
■ Plan, perform and supervise experiments; process and analyse experimental data; aggregate, interpret and present research results.
■ Get satisfactorily integrated in the AGS’ team.
■ Be involved in the research and development activities performed by AGS in the highly competitive and challenging space of gene and drug delivery platforms.
■ Ph.D. degree inbiology, biochemistry, or related field, or physician.
■ 3+ years of research experience in academic and/or industry environment.
■ Research experience supported by original publications in recognized scientific journals.
■ Hands-on experience with relevant methods and techniques to be used in the proposed job.
■ Be highly motivated, results-oriented with ability to work and deliver.
■ Excellent verbal and written communication skills in French and English.
■ Previous experience in a biotech environment.
■ Hands-on experience in the fields of exosomes or extracellularvesicles.
■ Competitive pay.
■ Highly motivating and creative working environment.
■ Challenging research and development projects.
■ Stimulating space for those who want to go beyond the expected and take risks.
■ You will build your own future.
■ Team-work - we will get there together.
■ An opportunity to make your mark at a growing start-up.
■ CDI (Contrat de Durée Indeterminée).
■ As soon as we find the right candidate.
We strongly believe AGS’ science and technology can make a difference for patients worldwide. Gene and drug therapies of tomorrow need delivery platforms that are less invasive than current alternatives, and that can deliver the therapeutic molecules safely and effectively, and that can overcome particularly stringent biological barriers to access inaccessible tissues like the gastro-intestinal tract, the brain, the choroid-retina, the lungs.
We explore and develop the potential of our technology, by putting a strong emphasis in R&D challenges, and in creating new disrupting paradigms to bypass long-standing narrow-scoped scientific assumptions.
You will have an opportunity to be a part of a highly innovative biotech, build on your skills and learn from your colleagues - but also enjoy our friendly and creative atmosphere.
If you are looking for an inspiring, challenging, ambitious, and fast-moving work environment - AGS is your place!
If you wish to apply, please write to:
Lila Drittanti - ld@ags-tx.com
We will respond to all candidates but reserve the right to invite only the selected ones for an interview (on-line and/or on-site). Please note that the selected candidates will be evaluated in a several-step process that may take a few weeks.
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AGS is expanding its team and actively seeking candidates for all newly created positions.
February 2024
January 2024
