AGS

2-billion-years-old

technology, unleashed.

Extracellular Vesicles from Microalgae (MEV)
as Delivery Systems for Human Therapeutics and Vaccines.

As an innovative Biopharmaceutical Company, we engineer the natural machinery of billion-years-old microalgae to develop novel therapeutics and novel vaccines.

AGS THERAPEUTICS
AGS-TX

2-billion-year-old

technology, unleashed .
Extracellular Vesicles from Microalgae (MEV)
as Drug Delivery Systems for Human Therapeutics.

As a Biopharmaceutical Company, we engineer the billion-years-old natural machinery of microalgae to develop therapeutics delivered by microalgae extracellular vesicles (MEVs).

AGS THERAPEUTICS
TIMES
Awarded template of the year 2021
GOOD
COMPANY
Best rated Webflow template
App Store
Customer Reviews
STARTUP
REPORT
Easy to use and to customize
QUICK
REPORT
Clean and minimalist design
AGS-TX

2-billion-year-old technology, live.

AGS THERAPEUTICS

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.

TIMES
Awarded template of the year 2021
GOOD
COMPANY
Best rated Webflow template
App Store
Customer Reviews
STARTUP
REPORT
Easy to use and to customize
QUICK
REPORT
Clean and minimalist design
Easy to Use

Rerum facilis est et expedita distinctio nam libero

Fast response

Rerum facilis est et expedita distinctio nam libero

Friendly UI

Rerum facilis est et expedita distinctio nam libero

Explore our platform of siRNA therapeutics

R&D programs

As dramatically seen with the current COVID-19 pandemic, therapeutics against viral and bacterial infections still represent a significant medical problem as new or resistant pathogens emerge. There is a vast, urgent, unmet need to bring rapid and adapted solutions against emerging diseases.

Bronchial Mucosa

Bronchial Mucosa

Bronchial Mucosa, bronchial Epithelium Non sint porro nam sunt assumenda expedita autem. Et autem odio et dolores dignissimos quo harum voluptatibus aut numquam unde! Non molestiae asperiores ut fugit porro vel enim dolores et quia architecto in facere odit! Est cumque atque ut ullam facilis non placeat odio id aliquid unde sed ullam dolorem cum sunt deserunt qui expedita porro.

CNS

CNS

Smell receptor to Brain and Nervous system CNS (Brain) Non sint porro nam sunt assumenda expedita autem. Et autem odio et dolores dignissimos quo harum voluptatibus aut numquam unde! Non molestiae asperiores ut fugit porro vel enim dolores et quia architecto in facere odit! Est cumque atque ut ullam facilis non placeat odio id aliquid unde sed ullam dolorem cum sunt deserunt qui expedita porro.

CNS

CNS

Brain and Nervous system 6 CNS (Brain) Neuron (synapse) Non sint porro nam sunt assumenda expedita autem. Et autem odio et dolores dignissimos quo harum voluptatibus aut numquam unde! Non molestiae asperiores ut fugit porro vel enim dolores et quia architecto in facere odit! Est cumque atque ut ullam facilis non placeat odio id aliquid unde sed ullam dolorem cum sunt deserunt qui expedita porro.

Digestive tract

Digestive tract

Microvillus of the small intestine Non sint porro nam sunt assumenda expedita autem. Et autem odio et dolores dignissimos quo harum voluptatibus aut numquam unde! Non molestiae asperiores ut fugit porro vel enim dolores et quia architecto in facere odit! Est cumque atque ut ullam facilis non placeat odio id aliquid unde sed ullam dolorem cum sunt deserunt qui expedita porro.

Duodenum

Duodenum

Non sint porro nam sunt assumenda expedita autem. Et autem odio et dolores dignissimos quo harum voluptatibus aut numquam unde! Non molestiae asperiores ut fugit porro vel enim dolores et quia architecto in facere odit! Est cumque atque ut ullam facilis non placeat odio id aliquid unde sed ullam dolorem cum sunt deserunt qui expedita porro.

Liver

Liver

Non sint porro nam sunt assumenda expedita autem. Et autem odio et dolores dignissimos quo harum voluptatibus aut numquam unde! Non molestiae asperiores ut fugit porro vel enim dolores et quia architecto in facere odit! Est cumque atque ut ullam facilis non placeat odio id aliquid unde sed ullam dolorem cum sunt deserunt qui expedita porro.

Respiratory epithelium

Respiratory epithelium

Non sint porro nam sunt assumenda expedita autem. Et autem odio et dolores dignissimos quo harum voluptatibus aut numquam unde! Non molestiae asperiores ut fugit porro vel enim dolores et quia architecto in facere odit! Est cumque atque ut ullam facilis non placeat odio id aliquid unde sed ullam dolorem cum sunt deserunt qui expedita porro.

Skin

Skin

Non sint porro nam sunt assumenda expedita autem. Et autem odio et dolores dignissimos quo harum voluptatibus aut numquam unde! Non molestiae asperiores ut fugit porro vel enim dolores et quia architecto in facere odit! Est cumque atque ut ullam facilis non placeat odio id aliquid unde sed ullam dolorem cum sunt deserunt qui expedita porro.

Spleen

Spleen

Non sint porro nam sunt assumenda expedita autem. Et autem odio et dolores dignissimos quo harum voluptatibus aut numquam unde! Non molestiae asperiores ut fugit porro vel enim dolores et quia architecto in facere odit! Est cumque atque ut ullam facilis non placeat odio id aliquid unde sed ullam dolorem cum sunt deserunt qui expedita porro.

Urogenital

Urogenital

Topical - Urinary bladder mucosa - Mucosal epithelia (urogenital mucosa) Non sint porro nam sunt assumenda expedita autem. Et autem odio et dolores dignissimos quo harum voluptatibus aut numquam unde! Non molestiae asperiores ut fugit porro vel enim dolores et quia architecto in facere odit! Est cumque atque ut ullam facilis non placeat odio id aliquid unde sed ullam dolorem cum sunt deserunt qui expedita porro.

Vaginal mucosa

Vaginal mucosa

Non sint porro nam sunt assumenda expedita autem. Et autem odio et dolores dignissimos quo harum voluptatibus aut numquam unde! Non molestiae asperiores ut fugit porro vel enim dolores et quia architecto in facere odit! Est cumque atque ut ullam facilis non placeat odio id aliquid unde sed ullam dolorem cum sunt deserunt qui expedita porro.

Bronchial Mucosa

Bronchial Mucosa, bronchial Epithelium Non sint porro nam sunt assumenda expedita autem. Et autem odio et dolores dignissimos quo harum voluptatibus aut numquam unde! Non molestiae asperiores ut fugit porro vel enim dolores et quia architecto in facere odit! Est cumque atque ut ullam facilis non placeat odio id aliquid unde sed ullam dolorem cum sunt deserunt qui expedita porro.

CNS

Smell receptor to Brain and Nervous system CNS (Brain) Non sint porro nam sunt assumenda expedita autem. Et autem odio et dolores dignissimos quo harum voluptatibus aut numquam unde! Non molestiae asperiores ut fugit porro vel enim dolores et quia architecto in facere odit! Est cumque atque ut ullam facilis non placeat odio id aliquid unde sed ullam dolorem cum sunt deserunt qui expedita porro.

CNS

Brain and Nervous system 6 CNS (Brain) Neuron (synapse) Non sint porro nam sunt assumenda expedita autem. Et autem odio et dolores dignissimos quo harum voluptatibus aut numquam unde! Non molestiae asperiores ut fugit porro vel enim dolores et quia architecto in facere odit! Est cumque atque ut ullam facilis non placeat odio id aliquid unde sed ullam dolorem cum sunt deserunt qui expedita porro.

Digestive tract

Microvillus of the small intestine Non sint porro nam sunt assumenda expedita autem. Et autem odio et dolores dignissimos quo harum voluptatibus aut numquam unde! Non molestiae asperiores ut fugit porro vel enim dolores et quia architecto in facere odit! Est cumque atque ut ullam facilis non placeat odio id aliquid unde sed ullam dolorem cum sunt deserunt qui expedita porro.

Duodenum

Non sint porro nam sunt assumenda expedita autem. Et autem odio et dolores dignissimos quo harum voluptatibus aut numquam unde! Non molestiae asperiores ut fugit porro vel enim dolores et quia architecto in facere odit! Est cumque atque ut ullam facilis non placeat odio id aliquid unde sed ullam dolorem cum sunt deserunt qui expedita porro.

Liver

Non sint porro nam sunt assumenda expedita autem. Et autem odio et dolores dignissimos quo harum voluptatibus aut numquam unde! Non molestiae asperiores ut fugit porro vel enim dolores et quia architecto in facere odit! Est cumque atque ut ullam facilis non placeat odio id aliquid unde sed ullam dolorem cum sunt deserunt qui expedita porro.

Respiratory epithelium

Non sint porro nam sunt assumenda expedita autem. Et autem odio et dolores dignissimos quo harum voluptatibus aut numquam unde! Non molestiae asperiores ut fugit porro vel enim dolores et quia architecto in facere odit! Est cumque atque ut ullam facilis non placeat odio id aliquid unde sed ullam dolorem cum sunt deserunt qui expedita porro.

Skin

Non sint porro nam sunt assumenda expedita autem. Et autem odio et dolores dignissimos quo harum voluptatibus aut numquam unde! Non molestiae asperiores ut fugit porro vel enim dolores et quia architecto in facere odit! Est cumque atque ut ullam facilis non placeat odio id aliquid unde sed ullam dolorem cum sunt deserunt qui expedita porro.

Spleen

Non sint porro nam sunt assumenda expedita autem. Et autem odio et dolores dignissimos quo harum voluptatibus aut numquam unde! Non molestiae asperiores ut fugit porro vel enim dolores et quia architecto in facere odit! Est cumque atque ut ullam facilis non placeat odio id aliquid unde sed ullam dolorem cum sunt deserunt qui expedita porro.

Urogenital

Topical - Urinary bladder mucosa - Mucosal epithelia (urogenital mucosa) Non sint porro nam sunt assumenda expedita autem. Et autem odio et dolores dignissimos quo harum voluptatibus aut numquam unde! Non molestiae asperiores ut fugit porro vel enim dolores et quia architecto in facere odit! Est cumque atque ut ullam facilis non placeat odio id aliquid unde sed ullam dolorem cum sunt deserunt qui expedita porro.

Vaginal mucosa

Non sint porro nam sunt assumenda expedita autem. Et autem odio et dolores dignissimos quo harum voluptatibus aut numquam unde! Non molestiae asperiores ut fugit porro vel enim dolores et quia architecto in facere odit! Est cumque atque ut ullam facilis non placeat odio id aliquid unde sed ullam dolorem cum sunt deserunt qui expedita porro.

ABOUT AGS

AGS is a biotech company developing innovative biomedicines based on extracellular vesicles from microalgae (MEV), a new kind of safe, targeted and highly versatile delivery system for therapeutic molecules from natural and synthetic biology designed to address a wide range of diseases.

Widespread use of innovative biologics -RNA, DNA, proteins, gene editing complexes, and gene expression plasmids - for the treatment of human diseases remains elusive due to the lack of an effective drug delivery system (DDS). The inability to deliver therapeutic doses to the right target in the body without affecting other organs or tissues or to overcome natural barriers – brain blood barrier or gut – has been a significant bottleneck in unleashing the power of the most advanced biologics as effective biomedicines for patients.

MEV have the potential to be effective drug delivery vehicles thanks to their ability to pass through the body’s natural barriers, and to carry biologics to specific tissues avoiding the premature degradation or inactivation.

AGS Technology Platforms

With a strong IP position as well as an experienced and dedicated team onboard, AGS develops biomedicines using its proprietary technology platforms: from the biomolecule design, the microalgae cell engineering, to MEV manufacturing at pre-industrial scale (AGS-M).

ABOUT OUR COLLABORATIVE SPACE
An organizing principle instigated by AGS Therapeutics' founders - informed by their transnational parcours and reflecting their collective vision, AGS Therapeutics consolidated a collaborative space aiming at coordinating the R&D in the field of MEVs-derived therapeutic solutions. From a local and transregional to a European and transatlantic network, this collaborative space allows its actors to respectively prosper as entities through the development of a common project.
ABOUT AGS

AGS is a biotech company developing innovative biomedicines based on extracellular vesicles from microalgae (MEV), a new kind of safe, targeted and highly versatile delivery system for therapeutic molecules from natural and synthetic biology designed to address a wide range of diseases.

Widespread use of innovative biologics -RNA, DNA, proteins, gene editing complexes, and gene expression plasmids - for the treatment of human diseases remains elusive due to the lack of an effective drug delivery system (DDS). The inability to deliver therapeutic doses to the right target in the body without affecting other organs or tissues or to overcome natural barriers – brain blood barrier or gut – has been a significant bottleneck in unleashing the power of the most advanced biologics as effective biomedicines for patients.

MEV have the potential to be effective drug delivery vehicles thanks to their ability to pass through the body’s natural barriers, and to carry biologics to specific tissues avoiding the premature degradation or inactivation.

AGS Technology Platforms

With a strong IP position as well as an experienced and dedicated team onboard, AGS develops biomedicines using its proprietary technology platforms: from the biomolecule design, the microalgae cell engineering, to MEV manufacturing at pre-industrial scale (AGS-M).

ABOUT OUR COLLABORATIVE SPACE
An organizing principle instigated by AGS Therapeutics' founders - informed by their transnational parcours and reflecting their collective vision, AGS Therapeutics consolidated a collaborative space aiming at coordinating the R&D in the field of MEVs-derived therapeutic solutions. From a local and transregional to a European and transatlantic network, this collaborative space allows its actors to respectively prosper as entities through the development of a common project.
ABOUT AGS Tx

AGS is an innovative biopharmaceutical company which develops next generation therapeutics and vaccines (based on mRNA, siRNA, DNA, proteins, small molecules) delivered by Extracellular Vesicles from Microalgae (MEV).

AGS Technology Platforms

With a strong IP position as well as an experienced and dedicated team onboard, AGS works on proprietary technology platforms including microalgae cell engineering, biomolecule design, biopharmaceutical product development in vitro and in vivo, MEV manufacturing at lab and pre-industrial scale (see AGS-M), MEV bio-analytics and characterization.

At AGS, we strongly believe our science and technology can make a difference for patients worldwide. Gene and drug therapies are in great need of delivery platforms that can drive them to their therapeutic targets safely and effectively.
Therefore, we aim to explore the potential of our technology, by both staying focused on the R&D challenges that we face and developing our technology platforms and products.

ABOUT OUR COLLABORATIVE SPACE
An organizing principle instigated by AGS Therapeutics' founders - informed by their transnational parcours and reflecting their collective vision, AGS Therapeutics consolidated a collaborative space aiming at coordinating the R&D in the field of MEVs-derived therapeutic solutions. From a local and transregional to a European and transatlantic network, this collaborative space allows its actors to respectively prosper as entities through the development of a common project.

Management team

Manuel VEGA
Founder,
Chief Executive Officer
Lila DRITTANTI
Founder,
Chief Operating Officer
Marie-Hélène LEOPOLD
Founder,
Business Intelligence Officer

Scientific Advisory Board

Lionel NAVARRO
FR
Founder,
Researcher at IBENS - CNRS, Paris.
Eric QUEMENEUR
FR
Executive VP, CSO, TRANSGENE, Strasbourg.
Director Research – Industrial Partnerships, CEA (1990 – 2014).
Jérémy PRUVOST
FR
Director, ALGOSOLIS / GEPEA, Nantes.
Elina ZUNIGA
USA
Professor UCSD, San Diego.
Amanda LUND
USA
Associate Professor, NYU, New York
ABOUT OUR COLLABORATIVE SPACE
AGS has originated a collaborative space aiming at boosting the field of MEV-derived solutions. This collaborative space allows its members to develop technologies, knowledge, and value and to prosper themselves through a joint work with AGS.

Partners

AGS-TX

Technology Platform

Our highly versatile, proprietary technology platform can be applied to a diversity of targets and purposes. As part of our initial focus on anti-infectives, we develop microalgae-induced gene silencing therapeutics, delivered by microalgae extracellular vesicles, aimed at killing or blocking the replication of human pathogens.

MIGs Platform

Microalgae Genetic Engineering

Our proprietary platform enables the generation of stable producer cell lines from genetically engineered microalgae, for therapeutics applications. The microalgae are then used to express custom, targeted RNAi (siRNA or miRNA) which are directly embedded, by the same microalgae, into their own extracellular vesicles.

RNAi Biotherapeutics

Antimicrobial Precision Killing

The therapeutic agents (RNAi) produced by our initial set of microalgae cell lines are designed to be pathogen-killers independent of their antibiotic resistance (bacteria) and their immunogenicity or escape mutability (viruses). Welcome the next generation of antibacterial and antiviral biotherapeutics.

RNAi targets

Gene Silencing Shotgun

We take advantage of the versatility of RNAi, used to down-regulate the expression of target genes in specific hand-picked gene sequences, and aim at any and all regions, both structural and functional, where essential, pathogenic, or resistance genes are present.
All the action happens simultaneously, like a shotgun.

MEVs

Natures’ own Delivery System

True to EVs’ natural role as primary communication channel between cells, we engineered our microalgae-based EVs (MEVs) to serve as Drug Delivery System (DDS), to carry, protect, and deliver their cargo right into human or bacterial cells. By design, MEVs can be either generic (targeting a variety of tissues and allowing for multiple administration routes) or specific.

Safe system

The Ideal Biological System

Microalgae are free from human pathogens (e.g. viruses, mycoplasma), and their MEVs are non-toxic as well as non-immunogenic for humans. Unlike most of the current pharmaceutical industry, which uses animal cells or synthetic biology for the manufacturing of proteins, viral vectors, and EVs among others, our technology offers a safer alternative.

Simple process

The New Gold Standard

Requiring only light, water, and salts, microalgae-based biologics are produced and purified using inherently clean and simple processes, with low-to-no media supplements, that can easily be scaled-up in compliance with cGMP regulations. Equipped with cutting-edge Photo-Bioreactors (PBRs) and industry-standard Downstream Processing (DSP) tools, we achieve a high-yield, low-cost overall process.

__________________________________________________________________________________________________________
THIS IS OUR COMPANY

Management team

Manuel VEGA
Founder,
CEO
Lila DRITTANTI
Founder,
COO & Product Development
Lionel NAVARRO
Founder,
Scientific Advisor
Marie-Hélène LEOPOLD
Founder,
Corporate Development CCD

Advisory Board

Eric QUEMENEUR
FR
Executive VP, CSO, TRANSGENE
(since 2014).
Director Research – Industrial Partnerships, CEA (1990 – 2014).
Alex CHANAS
UK
Non-executive Director at several health companies (since 2011).
Executive Director, Worldwide Business Development, PFIZER (1997 – 2011).
Ron NEWBOLD
USA
Chief Business Officer, SPINOGENIX Inc.
(since 2020).
Senior VP, Chief Business Officer US, OTSUKA Pharmaceutical (2017 – 2019).
VP External R&D Innovation, PFIZER (2010-2017).
Jérémy PRUVOST
FR
Director, ALGOSOLIS.
Director, GEPEA.
Head of Research, Microalgae, GEPEA (2011-2018).
Co-Director, SPI Doctoral School, Univ. Nantes (2012-2016).
Fayza DABOUSSI
FR
CSO, TWB.
Research Director, INRA.
VP, Synthetic Biology, CELLECTIS (2008-2014).
CAREERS

Job Openings

AGS Tx is expanding its team and actively seeking candidates for ten newly created positions.

AGS
CONTACT

Let's talk

We welcome biotech companies eager to collaborate, researchers looking to expand our body of knowledge, investors funding the next generation of bio-platforms, and professionals ready to be part of the future of biotech.

Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.